“ 5-FU inhibited the growth of CT26 tumors, but co-treatment with either LA or EA abrogated this effect.”
“Aldehyde dehydrogenase activity in the cancer stem cells (CSCs), in response to concurrent treatment with 5-FU and either LA or EA , was increased compared with 5-FU treatment alone.”
“In addition, increased inhibition of growth was observed following concurrent treatment with EA and 5-FU.”
“Sequential treatment of LA followed by 5-FU abrogated the anticancer effects of 5-FU, and treatment with EA followed by 5-FU increased cancer cell growth in addition to abrogating the anticancer effects of 5-FU.”