“Among them, we found that apigenin enhanced the inhibitory effect of 5-FU on cell viability.”
“Furthermore, apigenin increased reactive oxygen species production, intracellular and intramitochondrial Ca2+ concentrations, and mitochondrial membrane potential upon cotreatment with 5-FU.”
“In addition, apigenin inhibited the upregulation of TS induced by 5-FU.”
“Therefore, apigenin may improve the therapeutic efficacy of 5-FU against CRC by suppressing TS, but apoptosis induction is mainly dependent on functional P53.”