Possible Interaction: Fluorouracil and Andrographolide

“Moreover, andrographolide displayed synergistic activity with 5-FU and PTX against DLD1 cells.”

“In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism.”

“Further study suggested that Andro promoted the antitumor effect of 5-Fu by down-regulating the level of p-MET.”

“In conclusion, these results confirmed the synergistic antitumor activity of Andro on CRC and provide evidence for possible clinical application of Andro for enhancing the antitumor effect of 5-Fu in CRC treatment.”

“In vitro studies showed that Andro synergistically enhanced the anti-proliferation effect of 5-Fu on HCT-116 cells due to increased apoptotic cells.”

“ ANDRO potentiates the cytotoxic effect of 5-FU in HCC cell line SMMC-7721 through apoptosis.”

“Surprisingly, … of ANDRO … 5-FU induces synergistic apoptosis, which could be corroborated to the increased caspase-8, p53 activity and the significant changes of Bax conformation in … cells, resulting in increased losses of mitochondrial membrane potential, increased release of cytochrome c, and activation of caspase-9 and caspase-3.”

“ AG might act as a chemosensitizer when co-administered with 5-FU , ADM and DDP, and the mechanism of reversal modulation of multidrug resistance by AG in the HCT-8/5-FU resistant cell line might be related to its downregulation of overexpression of P-170.”

“However, a remarkable inhibitory and apoptosis rate was shown when AG was co-administered with 5-FU , ADM and DDP, respectively.”

“In the present study, we reported that andrographolide sulfonate could significantly inhibit the growth of transplanted CT26 colon cancer in mice and improve survival when combined with 5-FU.”

“In combination with 5FU, andrographolide exhibited synergistic effect.”