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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Fluorouracil
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Intriguingly, the combination of LA and anticancer drugs (doxorubicin, 5-fluorouracil ) attenuated p53-mediated stabilization of p21 and resulted in synergistic killing in CRC cells in a p53-dependant manner.”
Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation“Collectively, these findings demonstrate that LA induces CRC cell death independent of their p53 status and potentiates the cytotoxicity of 5-FU without causing DNA damage on its own, which makes it a candidate for tumor therapy.”
“Finally, we provide evidence that LA increases the cytotoxic effect induced by the anticancer drug 5-FU as revealed by significantly enhanced cell death rates in HCT116 and CaCO-2 cells.”
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