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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fluorouracil
supplement:
Allicin
Research Papers that Mention the Interaction
“Cells combined treatment with allicin and 5-FU increased intracellular reactive oxygen species (ROS) level, reduced mitochondrial membrane potential (ΔΨm), activated caspase-3 and PARP, and down-regulated Bcl-2 compared with DMSO, allicin and 5-FU treated alone.”
“In the present study, we demonstrated that allicin enhanced 5-fluorouracil (5-FU) inducing cytotoxicity in HCC cells.”
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway.“Better results were obtained when a lower concentration of 5-FU was combined with allicin than the single-agent treatment at IC50.”
“In this study, we highlighted that the combination of allicin with 5-FU inhibited the cell migration and proliferation of colorectal and lung cancer cells.”
“The synergistic antitumor effect of 5-FU combined with allicin was visible against lung and colorectal carcinoma cells.”
“Indeed, the combination of allicin and 5-FU significantly decreased the expression of the P-gp and CD44 proteins (P<0.05).”
“RESULTS Here, we found that the combination of al icin wi th 5-F U si gnificantly increased apoptosis compared to 5-FU alone (P<0.05).”
“Thus, the combination of 5-FU with adjuvants such as allicin may overcome multidrug resistance (MDR).”
Allicin Reduces 5-fluorouracil-resistance in Gastric Cancer Cells through Modulating MDR1, DKK1, and WNT5A Expression.
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