Possible Interaction: Fluorides and Vitamin C

“The antioxidant potential of … at 10 ppm fluoride concentration and PK at all three dose levels (i.e., 100, 200 … induced lipid peroxidation (p < 0.05) and increased the levels of total ascorbic acid , superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and … < 0.05) in a dose-dependent manner.”

“ Fluoride added to drinking water at concentrations of 50 and 70 ppm provided highly significant increases in the ascorbic acid concentration in tissues but was without effect on the serum alkaline phosphatase and cholesterol.”

“Adequate calcium and vitamin C in the diet were found to mitigate the toxic effects of fluoride.”

“Iodoacetate and fluoride at low concentrations decreased ascorbic acid loss from cells during incubation; at high concentrations they increased loss.”

“ Ascorbic acid and Ginkgo biloba were found to augment the reversal of learning and memory deficits caused by fluoride ingestion”

“Treatment with Calcium, Vitamin D and Vitamin C resulted a significant reduction in serum fluoride and SOD and increase in urinary fluoride.”

“Treatment with Calcium, Vitamin D and Vitamin C showed a significant reduction in serum fluoride and SOD and increase in urinary fluoride.”

“Because fluoride inhibits the enzyme competitively with respect to ascorbic acid , it is proposed that the type 2 copper is part of the ascorbate binding site.”