Salivary fluoride content after toothbrushing with a sodium fluoride and an amine fluoride dentifrice followed by different mouthrinsing procedures.

 dentifrices reduces the salivary fluoride concentration of both an amine and a 

CaF2 in enamel biopsies 6 weeks and 18 months after fluoride treatment.

Histopathological changes of renal tissue following sodium fluoride administration in two consecutive generations of mice. Correlation with the urinary elimination of fluoride.

 treatments produce some pathological aspects of the kidneys and influence the urinary elimination of 

Inhibitory effect of fluoride on the secretion of insulin

, fasting human volunteers showed increased 

 (5–15 μM) together with a significant fall of plasma insulin levels.

Enamel remineralization potential of arginine-fluoride varnish in a multi-species bacterial pH-cycling model.

 uptake and remineralization potential of the conventional 5% NaF varnish.

Effect of fluoride concentration in adhesives on morphology of acid-base resistant zones.

 from the adhesive linearly increased with higher 

Penetration of Fluoride into Natural Plaque Biofilms

 concentrations near the saliva interface, while concentrations near the enamel surface remained low.

Effect of fluoride addition on the properties of dental alginate impression materials

 release than the control group (p<0.05).

Fluoride varnish concentration gradient and its effect on enamel demineralization.

 concentration gradient exists in tubes of 

An ex vivo investigation into the fluoride release and absorption profiles of three orthodontic adhesives.

Limerick glass and Fuji-Ortho L.C. showed an increase (P < 0.01) in

 that decreased both with time and subsequent exposures to fluoride supplement.

Neutron activation analysis of fluoride release after treatment with a fluoride varnish in vitro.

Developmental Enamel Defects in Children with Different Fluoride Supplementation – a Follow–Up Study

 with water, food, dental fluoride preparations, or in particular fluoride supplements, such as 

[Fluoride bioavailability from sodium fluoride alone or in association with different calcium salts].

 is significantly decreased by the association to 

 of hydroxyapatite but not of tri-calcium phosphate.

[Differential therapy of osteoporosis].

[The passage of fluoride across the placenta. An intra-uterine study].

 was statistically higher than in the controlled group (2.6 mumol/l and less than 1 mumol/l); this demonstrates in a statistically … placenta in the fifth and sixth months of pregnancy which is the time when the milk teeth start to develop in the uterus.

[Value of bone fluoride determination in osteoporotic patients treated with sodium fluoride].

 concentration could vary by up to three times from a patient to another.

Orthodontic appliances and enamel demineralization. Part 2. Prevention and treatment of lesions.

 mouth rinsing with a 0.2% solution sodium fluoride (

) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely.

Fluoride in Saliva and Plaque Following Use of Fluoride-containing Mouthwashes

 concentrations increased significantly with increasing applied 

 concentration in the range 0-1000 ppm F (0-0.053 mol/L).

Attainment of therapeutic fluoride levels in serum without major side effects using a slow‐release preparation of sodium fluoride in postmenopausal osteoporosis

In 8 normal volunteers, a single administration of

 (25 mg) caused a slow rise and gradual decline in 

 concentration, thus avoiding sharp peaks produced by a rapid‐release preparation.

Evaluation of an autopolymerizing fissure sealant as a vehicle for slow release of fluoride.

 was significantly greater than that released from the other test specimens from days 31 to 90.

 increased over the duration of the in vitro study and with the level of 

Uptake and retention of alkali-soluble and alkali-insoluble fluoride in sound enamel in vivo after mouthrinses with 0.05% or 0.2% NaF.

 content of the outer enamel layer (≈ 5 μm) by 15.9%.

Some effects of bone meal and NaF tablets on the composition of saliva.

Tensile strength of the bond between resin to enamel etched with phosphoric acid containing fluoride.

 or SnF2 in the etching solutions highly increased the 

[Available fluoride from various drugs after oral application].

Magnesium-fluoride interrelationships in man. I. Effect of fluoride on magnesium metabolism.

, resulted in a two- to threefold increase of the urinary and fecal fluoride excretion.

Renal excretion of fluoride in renal failure and after renal transplantation.

Acute loading of such patients … fluoride in the form of

 from 40 mg to 60 mg/day … a twofold to threefold increase of 

 concentrations, slight increases in urinary fluoride excretion, and heavy tissue absorption, … that prior fluoride loading of the skeleton had not taken place.

Studies of fluoride and calcium metabolism in patients with osteoporosis.

, the fluoride balances ranging from +11.2 to +17.7 mg/day.

Oral telemetry of fluoride ion activity.

 (0.7 mg F) placed in the vestibular fold on the electrode side resulted in an increase of 

 to a maximum of 150 ppm F within 12 min and in a gradual decrease to the original activity level in 40 min.

Release of Fluoride into Saliva after Topical Fluoride Application

 + Na2HPO4 treatment was higher than that after NaF treatment.

Sodium Fluoride and Cell Growth

 added to culture media to give an augmented 

Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model.

 deposition in the brain which in turn caused increase levels of epinephrine, histamine, serotonin, and glutamate and decreased levels of norepinephrine, acetylcholine, and dopamine in a dose-dependent manner.

Effects of perinatal fluoride exposure on the expressions of miR-124 and miR-132 in hippocampus of mouse pups.

Open field test showed that compared to the control group,

 exposure significantly decreased the number of entries into the center zone in 100 mg/L 

Alterations in epididymal proteomics and antioxidant activity of mice exposed to fluoride

 decreased the antioxidant activity of epididymis, especially glutathione and glutathione-related enzymes, as well as iTRAQ results, providing new explanations for the low sperm quality induced by 

Toxicity assessment of sodium fluoride in Drosophila melanogaster after chronic sub-lethal exposure.

The alterations in the mentioned parameters can be due to increased body Fluoride ion (F-) concentration since the analysis with ion electrode analyzer revealed that

 concentration increased significantly with 

Effect of Fluoride on Endocytosis and Surface Marker Expression Levels of Mouse B Cells In Vitro

 at 50µM. NaF significantly enhanced CD80 expression at 50 µM and decreased CD86 expression at 500 µM. CD40 and CD138 expression on B cells … CD80 of B cells changed significantly at lower concentrations, whereas expression levels of CD138 and CD86 changed significantly at higher concentrations, suggesting that 

Effect of sodium fluoride on neuroimmunological parameters, oxidative stress and antioxidative defenses

Permeability of eroded enamel following application of different fluoride gels and CO2 laser

Intermediate permeability values were noted after

Influence of Methionine and Vitamin E on Fluoride Concentration in Bones and Teeth of Rats Exposed to Sodium Fluoride in Drinking Water

 concentration in both bones and teeth was found to be higher in the 

 and NaF + Met groups compared to the control group.

Sodium Fluoride Affects Proliferation and Apoptosis Through Insulin-Like Growth Factor I Receptor in Primary Cultured Mouse Osteoblasts

In summary, our findings suggest that the administration of

 affects the expression of IGF-IR in mouse osteoblasts, contributing to the proliferation and apoptosis induced by 

[The effect of alternating administration of aluminum chloride and sodium fluoride in drinking water on the concentration of fluoride in serum and its content in bones of rats].

 concentration in the femur as compared with control animals.

Fluoride uptake and resistance to further demineralisation of demineralised enamel after application of differently concentrated acidulated sodium fluoride gels

It is concluded that differently concentrated acidulated

 gels resulted in concentration-related significant uptake of 

 in carious-like demineralised enamel, leading to a better demineralisation protection with increasing fluoride concentration in the gel.

The effect of fluoride on the patterns of adherence of osteoclasts cultured on and resorbing dentine: a 3-D assessment of vinculin-labelled cells using confocal optical microscopy

The peripheral creeping of the contact region was more marked in the osteoclasts of the 15 mg/l

 cultures, and these cultures showed a decrease in pit depth and inhibition of osteoclastic movement in the presence of 

Modulation of fluoride toxicity in rats by calcium carbonate and by withdrawal of fluoride exposure.

Calcium Neutralizes Fluoride Bioavailability in a Lethal Model of Fluoride Poisoning

Methods: In preliminary studies, we determined that

 3.6 mM/kg intraperitoneally in the form of 

 was uniformly and rapidly fatal in a mouse model.

Influence of Coffee on Fluoride Metabolism in Rats

Abstract Concomitant intragastric administration of

 and coffee resulted in a significantly higher (P < 0.01) 

 level than intake of the same amount of fluoride with water.

A possible mechanism for increments of calcium and protein kinase C activity in kidney of experimental acute fluorosis.

On the other hand, we found that a single large dose of

 35 mg/kg, ip) to rats markedly increased the calcium content of the kidney (Suketa et al., 1977, 1986; Suketa and Kanamoto, 1983).

A possible mechanism for elevation of glucose-6-phosphatase activity in kidney and liver of fluoride-treated rats.

Glucose-6-phosphatase (EC 3.1.3.9) activity in kidney and liver was found to be markedly elevated 3 hr after a single large dose of

Changes of ion mobilizations and their related enzyme activities in the blood of fluoride-intoxicated rats.

 concentrations in plasma 3 hr after a single oral dose of 

 (5 mg/100 g body weight) were increased 26 times above the control, but the concentrations in erythrocytes and red cell membranes were increased only 1.8 and 1.5 times over the respective control levels.

Comparison of the anticaries effects in rats of NaF and SnF2 applied topically under a wide variety of experimental conditions.

The anticaries efficacy of fluoride (SnF2 or

) was significantly increased as the concentration of 

 and the frequency of application were increased.

The influence of dietary sodium fluoride on the utilization and metabolizable energy value of a poultry diet.

, reduces feed intake and the growth rate of chickens (Phillips et al., 1935; and Gardiner et al., 1959, 1961).

Alleviative Effects of Exercise on Bone Remodeling in Fluorosis Mice.

 in bone, altered histology of bone, and enhanced the activities of ALP and TRACP.

Fluoride bioavailability on demineralized enamel by commercial mouthrinses.

 and low pH presented significantly greater bioavailability of 

 on enamel than those with higher pH or lower NaF concentration.

Silicon-regulated antioxidant and osmolyte defense and methylglyoxal detoxification functions co-ordinately in attenuating fluoride toxicity and conferring protection to rice seedlings.

 accumulation, as a result of which the seedlings suffered severe oxidative stress, as evident from growth inhibition, reduction in seed germination, tissue biomass, …, decline in chlorophyll content, increases in electrolyte leakage, H2O2 content, lipid peroxidation (malondialdehyde content and lipoxygenase activity), protein carbonylation and protease activity.

A Nanomechanical Investigation of Three Putative Anti-Erosion Agents: Remineralisation and Protection against Demineralisation

The positive control solution (saturated hydroxyapatite solution) and 4500 mg/L

 significantly increased nanohardness D1-T by 19.9% and 24.1%, respectively, whereas 1400 mg/L fluoride as NaF, casein phosphopeptide-amorphous calcium phosphate mousse and negative control (deionised water) had no significant effect.

The effects of adding fluoride compounds to a fluoride-free glass ionomer cement on subsequent fluoride and sodium release.

 significantly enhanced release of both ions although 

 was less than from a glass containing 5% fluoride.

Fluoride release and uptake characteristics of aesthetic restorative materials.

Fluoride release and uptake in vitro from a composite resin and two orthodontic adhesives.

 from all materials, with near pre-exposure levels reached after 2-3 days.

Short-term fluoride release/uptake of glass ionomer restoratives.

 for all materials although it was not as high as the increase recorded after exposure to APF.

Purification, characterization and inhibition by fluoride of enolase from Streptococcus mutans DSM 320523.

 yielding Ki = Kii = 1.39 mM, but inhibition characteristics become competitive when tested above 10 mM. In the presence of only small amounts of … competitive with Ki = 0.9 mM, indicating that free fluoride ions in combination with phosphate are more effective in inhibiting S. mutans enolase.

Reduction of Acidurance of Streptococcal Growth and Glycolysis by Fluoride and Gramicidin

 was added to the media, the acid-sensitizing effect of 

 was evident in major shifts in the initial glucose levels for transition from glucose-limited to acid-limited growth to 0.1 and 0.2% for S. mutans and S. salivarius, respectively.

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Possible Interaction: Fluorides and Sodium Fluoride

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Research Papers that Mention the Interaction