supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Fluorides
drug:
Sevoflurane
Research Papers that Mention the Interaction
“The concentration of fluoride increased during sevoflurane anesthesia (15.0 +/- 4.8 mumol/l with lithiumhydroxide versus 21.9 +/- 4.0 mumol/l with Drägersorb 800 after 60 mins).”
[The use of lithium hydroxide for carbon dioxide absorption prevents formation of compound A during sevoflurane anesthesia].“ Sevoflurane , a new volatile inhalational agent, undergoes biotransformation to fluoride which is potentially nephrotoxic.”
“Serum concentrations of fluoride were significantly greater after sevoflurane than after halothane anaesthesia.”
“The levels of fluoride ions correlated with the degree of exposure to sevoflurane in MAC‐hours.”
“ Peak fluoride and fluoride measured at 24 hr were higher with sevoflurane compared with other inhaled anesthetics.”
“The main hypothesis was that biotrans-formation of sevoflurane has exacerbated a chronic exposure to fluoride.”
“A certain disadvantage and source of potential nephrotoxicity result from the metabolism of sevoflurane (2-5%) to anorganic fluoride and degradation to compound A in carbon dioxide absorbents.”
“ Fluoride concentrations have exceeded 50 microM in approximately 7% of sevoflurane patients.”
“ Sevoflurane undergoes considerable metabolism, producing free fluoride ion , with plasma concentrations proportional to dose and duration of anaesthesia exceeding 50 μM in approximately 7% of patients.”
“In contrast, studies using rabbits have found that plasma concentrations and urinary excretion of fluoride ion are dose-dependent up to 3% inspired sevoflurane.”
Relationship of Inspired Anesthetic Concentration to Plasma Concentration and Urinary Excretion of Sevoflurane Metabolites in Rats
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback