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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“This deficiency has arisen not just from decreased consumption of selenium in the last 30 years, but also from increased consumption of zinc and fluoride , which may antagonize the effect of selenium.”
Is the changing pattern of colorectal cancer caused by selenium deficiency?“ Fluoride causes chronic toxic effects and selenium modulates cellular activities through signal transduction in human cells.”
“The toxicity of fluoride can be reduced by selenium , at least partially via the suppression of intracellular oxidative stress.”
“Microradiographs of the specimens showed that the radiopacities of the decalcified dentin layers in RB and AF groups with fluoride release were significantly higher than those in SE or control groups without fluoride release.”
“ Selenium treatment reduced these kinds of toxicity of fluoride through raising GSH content, reducing LPO level, LDH and AST activity and percentage of apoptosis bodies.”
“The results indicate that selenium can attenuate apoptosis and AMPK phosphorylation in the NRK-52E cell induced with fluoride.”
Selenium attenuates apoptosis and p-AMPK expressions in fluoride-induced NRK-52E cells“Fluorosis could induce the decline of blood antioxidant capacity and the fluidity of erythrocyte membrane, as evident in this study, and Se at different levels possess some antagonistic effects on blood induced by fluoride.”
“We wanted to demonstrate a possible protective effect of selenium on the toxic effect of fluoride.”
“As evident in this study the antioxidative nature of selenium coupled with its reversal effect on metabolic enzymes in brain of mice treated with fluoride suggests its use as antidote agent against fluorosis.”
“… selenium … fluoride induced alterations in the activities of pro-oxidative (xanthine oxidase (XOD), lipid peroxidation (LPO) free radical scavenging, [catalase, superoxide dismutase (SOD), glutathione-s-transferase (…), aspartate aminotransferase (AAT), creatine phosphokinase (CPK), acid phosphatase (AP), alkaline phosphatase (ALP)] enzymes along with fluoride and selenium levels in brain of mice.”
“It was found that combined administration of fluoride and proper concentration of selenium could decrease the toxic effect of fluoride.”
“The results suggested that selenium might antagonize the neurotoxicity of fluoride on behavior and morphology.”
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