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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Fluorides and Phenytoin



Research Papers that Mention the Interaction

Fluoride and phenytoin together produced bigger increases in each parameter than did each agent alone.
In summary, fluoride and phenytoin act in concert to stimulate bone formation and increase trabecular bone volume without causing mineralization defects in vivo and thus, may be a potential combination therapy for low bone mass in osteoporosis.
Phenytoin and fluoride together also significantly reduced (by 36%) the mineralization lag time, indicating that these agents did not promote osteomalacia.
The combined effect of fluoride and phenytoin on each serum and bone formation parameter appeared to be less than additive.
Calcified Tissue International  •  2004  |  View Paper
Prolonged treatment with fluoride also lengthened the sleeping time induced by pentobarbital and increased the protective effect of diphenylhydantoin against electroshock.
Toxicology and applied pharmacology  •  1961  |  View Paper