Possible Interaction: Fluorides and Norethindrone

“In conclusion, these findings led us to speculate that the … of NET and fluoride act through different mechanisms, and that NET at low doses has a … on the osteogenic effects of fluoride , and as such NET may be used in concert … fluoride to increase osteoblast proliferation, differentiation, and activity.”

“In summary, we … osteogenic effects of fluoride … NET were additive when cells were treated with both agents concurrently; (2) a 24‐h pretreatment with picomolar doses of NET potentiated … of fluoride in human TE85 osteosarcoma cells; and (3) pretreatment with NET produced a subsequent fluoride response that was synergistic.”

“In the present study, we investigated the possibility that NET interacts with another osteogenic agent, i.e., fluoride , to stimulate human TE85 osteosarcoma cell proliferation, differentiation, and activities.”

“… NET for 24 h followed by a … dose (i.e., 100 μM) of fluoride for an additional 24 h significantly and synergistically potentiated the effects of fluoride on the [3H]thymidine incorporation, … activity, collagen synthesis, and osteocalcin secretion, compared with those with the subsequent vehicle (0.05% ethanol) treatments.”