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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Fluorides and Nitric Oxide

supplement:

Fluorides

Research Papers that Mention the Interaction

Excessive exposure to fluoride inhibited the synthesis of NO.
Biological Trace Element Research  •  2018  |  View Paper
We suggest the mechanism of fluoride injuring soft tissues as follows: fluoride causes excessive production of NO , LPO and oxygen free radicals, which can damage seriously the structure and function of soft tissues.
Environmental toxicology and pharmacology  •  2003  |  View Paper
Sub-… to fluoride at a dose of 20mg/kgb.w./day for 30 days caused significant alteration in pro-oxidant/… status of brain tissue as reflected by perturbation of reduced glutathione content, increased lipid peroxidation, protein carbonylation, nitric oxide and free hydroxyl radical production … decreased activities of antioxidant enzymes.
Environmental toxicology and pharmacology  •  2014  |  View Paper
The applied fluoride caused increase of nitric oxide level ( NO ), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2010  |  View Paper