supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Fluorides
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Excessive exposure to fluoride inhibited the synthesis of NO.”
“The PI3K/AKT/eNOS pathway played a crucial role in the reduced expression of NO caused by excessive fluoride exposure.”
Preliminary Study of Mechanisms of Fluoride-Induced Suppression of Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells“Sub-… to fluoride at a dose of 20mg/kgb.w./day for 30 days caused significant alteration in pro-oxidant/… status of brain tissue as reflected by perturbation of reduced glutathione content, increased lipid peroxidation, protein carbonylation, nitric oxide and free hydroxyl radical production … decreased activities of antioxidant enzymes.”
Protective effect of resveratrol on fluoride induced alteration in protein and nucleic acid metabolism, DNA damage and biogenic amines in rat brain.“The applied fluoride caused increase of nitric oxide level ( NO ), intensified lipid peroxidation (TBARS) and decreased total antioxidant status in serum (TAS), brain, kidney and liver.”
“We suggest the mechanism of fluoride injuring soft tissues as follows: fluoride causes excessive production of NO , LPO and oxygen free radicals, which can damage seriously the structure and function of soft tissues.”
Fluoride causing abnormally elevated serum nitric oxide levels in chicks.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback