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Last Updated: 3 months ago

Possible Interaction: Fluorides and Methoxyflurane

supplement:

Fluorides

Research Papers that Mention the Interaction

The most important difference observed between the two groups was the significantly elevated blood level of inorganic fluoride found postoperatively in the methoxyflurane-treated patients.
JAMA  •  1973  |  View Paper
Although both sevoflurane and methoxyflurane may produce plasma fluoride concentrations in excess of 50 microM, they have not produced the same nephrotoxic effects.
Anesthesia and analgesia  •  1995  |  View Paper
Renal damage due to methoxyflurane may be caused by F- which is released during its biotransformation while, in the group of halogenated inhalation anesthetics, only chloroform is a true hepatotoxic substance.
Der Anaesthesist  •  1975  |  View Paper
In a study of 47 patients exposed to methoxyflurane a significant correlation was found between the dose of methoxyflurane and the urine fluoride concentration on the first and second days after exposure.
British journal of anaesthesia  •  1974  |  View Paper
Consequently, the area under the fluoride curve is much greater after methoxyflurane anaesthesia than after either enflurane or isoflurane.
Peak fluoride levels also are considerably higher after methoxyflurane anaesthesia than after administration of the other two agents.
Canadian Anaesthetists' Society journal  •  1984  |  View Paper
The studies lend support to the contention that the concentrating defect associated with methoxyflurane may be due to inorganic fluoride , but do not prove such a relationship.
The Journal of laboratory and clinical medicine  •  1972  |  View Paper
These studies indicate that inorganic fluoride is responsible for the acute polyuric renal lesion which occurs after methoxyflurane administration.
The Journal of pharmacology and experimental therapeutics  •  1974  |  View Paper
It is concluded that there is variation in the rate of metabolism of methoxyflurane to inorganic fluoride and in its nephrotoxic effects among various rat strains.
The Journal of pharmacology and experimental therapeutics  •  1973  |  View Paper