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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Fluorides
drug:
Methoxyflurane
Research Papers that Mention the Interaction
“The most important difference observed between the two groups was the significantly elevated blood level of inorganic fluoride found postoperatively in the methoxyflurane-treated patients.”
Renal function after methoxyflurane and halothane anesthesia.“Consequently, the area under the fluoride curve is much greater after methoxyflurane anaesthesia than after either enflurane or isoflurane.”
“The studies lend support to the contention that the concentrating defect associated with methoxyflurane may be due to inorganic fluoride , but do not prove such a relationship.”
“BACKGROUND: Increased inorganic fluoride levels after methoxyflurane exposure in the 1970s and prolonged intraoperative sevoflurane use have been suggested to be potentially nephrotoxic.”
“Although both sevoflurane and methoxyflurane may produce plasma fluoride concentrations in excess of 50 microM, they have not produced the same nephrotoxic effects.”
“Renal damage due to methoxyflurane may be caused by F- which is released during its biotransformation while, in the group of halogenated inhalation anesthetics, only chloroform is a true hepatotoxic substance.”
“The more rapid elevation and higher peak levels of serum ionic fluoride following methoxyflurane , and to a lesser extent following halothane, may reflect increased anesthetic biotransformation in obese compared with nonobese patients.”
“In one case with probable excessive methoxyflurane use, plasma fluoride level reached 73.4 μmol/1.”
“In a study of 47 patients exposed to methoxyflurane a significant correlation was found between the dose of methoxyflurane and the urine fluoride concentration on the first and second days after exposure.”
“These studies indicate that inorganic fluoride is responsible for the acute polyuric renal lesion which occurs after methoxyflurane administration.”
The etiology of methoxyflurane nephrotoxicity.
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