Possible Interaction: Fluorides and Magnesium

“The fluoride ion avidly binds to calcium and magnesium in the body, causing a usually rapid onset of hypocalcemia and hypomagnesemia within the body.”

“The interaction of fluoride produces a more stable lattice, resisting dissolution and favoring accretion, and tending to counteract the effects of carbonate and magnesium in forming mineral.”

“Although some recent in vitro findings indicate that extra magnesium in the fluid environment of cariogenic streptococci may protect them against the inhibitory action of fluoride , such magnesium changes do not seem possible in the human mouth under present or envisaged dietary conditions.”

“The enzyme requires Mg 2 + , is sulfhydryl dependent and is strongly inhibited by fluoride.”

“Inorganic elements, such as calcium, phosphorus, and magnesium , which have been shown to decrease the intestinal absorption of fluoride in animals were ineffective in man, while aluminum, given as aluminum-containing antacids, markedly decreased the intestinal absorption of fluoride and thereby decreased the retention of fluoride.”

“It was also shown for the first time that the concentrations of fluoride normally found in serum can enhance calcification in the presence of physiological concentrations of magnesium if the product of the calcium and phosphate concentrations is lower than normal.”

“Calcification in the dilute glycerophosphate solution (10/0/5.5) was blocked by fluoride in the presence of magnesium.”

“It was noted that magnesium content of waste oyster shell reacted with fluoride to form significant fractions of MgF2 whose corresponding peak was detected at 685.6-685.8 eV. For coated oyster shell, fluoride reacted with Ca, Mg, and Al.”

“Our study exemplifies that the surface coating of magnesium implant using a bioactive ceramic such as fluoridated hydroxyapatite may improve the biocompatibility of the implant to make it suitable as a commercialized biomedical product.”

“Our results show that both in the absence and in the presence of Rb(+), simultaneous addition of magnesium and fluoride stabilizes the Na,K-ATPase in an E2 conformation, presumably the E2Mg-MgF4 complex, that is unable to shift to E1 upon addition of Na(+).”