Possible Interaction: Fluorides and Isoproterenol

“Added vanadate (1-10 mM) increased basal by two to four-fold, had no effect on the isoproterenol response, but doubled the forskolin response at 3 mM. Added F- (10 mM) increased basal by 30-40-fold, decreased the isoproterenol response and potentiated the forskolin response.”

“ Fluoride … isoproterenol or choleragen or by incubation with fluoride prior to assay; inhibition, dependent on fluoride concentration, was maximal at 5.3 mM. Since maximal activity … level when assayed in the presence of fluoride, we infer that inhibition is reversible at a time when fluoride activation is relatively irreversible.”