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“Administration of isoniazid in human patients may increase the metabolism of enflurane and increase serum fluoride ion concentrations (1) to levels that may transiently impair renal function (2,3).”
“Following anaesthesia with enflurane, some patients receiving isoniazid have increased serum concentrations of fluoride ion , presumably because of induction of an isozyme of cytochrome P450 which is responsible for enflurane biodegradation.”