Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Fluorides and Isoflurane

supplement:

Fluorides

Research Papers that Mention the Interaction

Plasma fluoride ion concentrations increased (+1.36 ± 0.93 μM, P < 0.01) in patients receiving isoflurane but were unchanged (− 0.13 ± 0.50 μM) in patients receiving desflurane.
Canadian journal of anaesthesia = Journal canadien d'anesthesie  •  1991  |  View Paper
Enflurane and even isoflurane may, when used during prolonged operations, also yield anorganic fluoride levels in excess of 50 mumol/l.
Der Anaesthesist  •  1996  |  View Paper
Isoflurane may lead to fluoride accumulation after more than 1 day.
Drugs  •  1993  |  View Paper
As the serum fluoride level may continue to rise after isoflurane and as this level is approaching toxicity, the role of isoflurane sedation in the critically ill should be approached cautiously.
Anaesthesia  •  1992  |  View Paper
The concentrations of serum fluoride ion and organic fluorine increased significantly 15 min after the onset of inhalation of isofluorane.
Anesthesiology  •  1988  |  View Paper
Isoflurane , the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system.
Journal of the American Society of Nephrology : JASN  •  1998  |  View Paper
Plasma fluoride ion concentrations immediately after and 4 hours after exposure to isoflurane were approximately three times greater than values obtained in awake swine before anesthesia.
Anesthesia and analgesia  •  1989  |  View Paper
Fluoride release was enhanced approximately 2.5 to 3 times by halothane or isoflurane ; however, fluroxene inhibited fluoride release and did not enhance the loss of cytochrome P-450.
Anesthesia and analgesia  •  1987  |  View Paper