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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Fluorides
drug:
Isoflurane
Research Papers that Mention the Interaction
“ Plasma fluoride ion concentrations increased (+1.36 ± 0.93 μM, P < 0.01) in patients receiving isoflurane but were unchanged (− 0.13 ± 0.50 μM) in patients receiving desflurane.”
Metabolism of desflurane and isoflurane to fluoride ion in surgical patients“Enflurane and even isoflurane may, when used during prolonged operations, also yield anorganic fluoride levels in excess of 50 mumol/l.”
“ Isoflurane may lead to fluoride accumulation after more than 1 day.”
“As the serum fluoride level may continue to rise after isoflurane and as this level is approaching toxicity, the role of isoflurane sedation in the critically ill should be approached cautiously.”
“The concentrations of serum fluoride ion and organic fluorine increased significantly 15 min after the onset of inhalation of isofluorane.”
“ Isoflurane , the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system.”
Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.“ Plasma fluoride ion concentrations immediately after and 4 hours after exposure to isoflurane were approximately three times greater than values obtained in awake swine before anesthesia.”
“ Fluoride release was enhanced approximately 2.5 to 3 times by halothane or isoflurane ; however, fluroxene inhibited fluoride release and did not enhance the loss of cytochrome P-450.”
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