Possible Interaction: Fluorides and Heme Iron

“Additional experiments on the effect of azide, and fluoride , ferric ligands which produce a change of spin state of the heme iron , suggest that additional second order conformational changes may also come into play.”

“ Fluoride and cyanide readily bind to the sixth coordination position of the heme iron in the native form, thereby changing MnP into a typical high-spin, hexacoordinate fluoro adduct or a low-spin, hexacoordinate cyano adduct, respectively.”

“ Fluoride is known to ligate to the heme iron atom of leghemoglobin, and a simple explanation of the data is that acetic acid and fluoride compete for binding to the heme iron atom.”