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Last Updated: 3 years ago

Possible Interaction: Fluorides and Halothane

supplement:

Fluorides

drug:

Halothane

Research Papers that Mention the Interaction

“ Halothane attenuated contractions in rings evoked by serotonin, endothelin, and F- but lacked effect on phorbol-induced responses.”
Volatile Anesthetics and Agonist‐induced Contractions in Porcine Coronary Artery Smooth Muscle and Ca2+ Mobilization in Cultured Immortalized Vascular Smooth Muscle Cells
Anesthesiology  •  1994  |  View Paper
“An FIO2 of 0.10 during halothane anesthesia significantly enhanced reductive biotransformation, as indicated by plasma fluoride ion concentrations.”
Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs.
Anesthesiology  •  1990  |  View Paper
“ Fluoride release was enhanced approximately 2.5 to 3 times by halothane or isoflurane; however, fluroxene inhibited fluoride release and did not enhance the loss of cytochrome P-450.”
Stimulatory Effects of Halothane and Isoflurane on Fluoride Release and Cytochrome P‐450 Loss Caused by Metabolism of 2‐Chloro‐l, l‐difluoroethene, a Halothane Metabolite
Anesthesia and analgesia  •  1987  |  View Paper
“ Halothane anesthesia under hypoxic conditions caused a significant elevation in the plasma fluoride concentration.”
Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents.
Anesthesiology  •  1976  |  View Paper