Possible Interaction: Fluorides and Glucose

“ Fluoride inhibits the removal of glucose and the production of lactic acid by S. mansoni to the same degree.”

“Complete inhibition of glycolysis by fluoride can take as long as 4 h, during which time glucose can fall as much as 10 mg/dL (0.6 mmol/L) at room temperature (1), even in samples with normal blood cell counts.”

“The delay in fluoride’s prevention of glucose loss in blood samples is sometimes attributed to a postulated delay in the entry of fluoride ion into the blood cells in which the glycolytic enzymes reside.”

“The fasting serum fluoride levels correlated positively with the area under the glucose curve (r=0.80,p<0.01) in patients with impaired glucose tolerance.”

“ Fluoride (1 mmol/L), either pulsed with the glucose or provided continuously, reduced both the rate of change and the degree of fall in pH, and in doing so prevented the enrichment of S. mutans in the culture.”

“These processes depend upon the catabolism of glucose , which can be inhibited by fluoride (F-).”

“The inhibition was greater with higher … favoured by an acidic pH. Fluoride (20 ppm) … from glucose at acidic pH values but 4.4 ppm or less had little or no effect on its …. The CO2 released from glucose stimulated by fluoride arose exclusively from glucose-carbons 3 and 4.”

“ Glucose removal was greater when cyanide and fluoride were added to the medium than fluoride alone; however, triglyceride synthesis from palmitate did not show a parallel increase.”

“When glucose was added to saliva in the presence of fluoride there was a much greater inhibition of metabolism under anaerobic than aerobic conditions.”

“ Fluoride (48 mM) completely abolished the absorptive activity gradient for glucose along the small intestine.”