Possible Interaction: Fluorides and Glucose

“Complete inhibition of glycolysis by fluoride can take as long as 4 h, during which time glucose can fall as much as 10 mg/dL (0.6 mmol/L) at room temperature (1), even in samples with normal blood cell counts.”

“ Fluoride (225 and 900 ppm F(-)) inhibited lactate production from 10% glucose by 34% and 46%, respectively, along with the increase in 3-phosphoglycerate and the decrease in phosphoenolpyruvate in the EMP pathway in supragingival plaque.”

“The delay in fluoride ’s prevention of glucose loss in blood samples is sometimes attributed to a postulated delay in the entry of fluoride ion into the blood cells in which the glycolytic enzymes reside.”

“ Fluoride (1 mmol/L), either pulsed with the glucose or provided continuously, reduced both the rate of change and the degree of fall in pH, and in doing so prevented the enrichment of S. mutans in the culture.”

“These processes depend upon the catabolism of glucose , which can be inhibited by fluoride (F-).”

“Further, fluoride was shown to inhibit oxidation of [1- 14 C] glucose , and incubation of neutrophils with fluoride did not result in significant generation of chemiluminescence or iodination of cellular material, as did other soluble stimuli.”

“ Glucose removal was greater when cyanide and fluoride were added to the medium than fluoride alone; however, triglyceride synthesis from palmitate did not show a parallel increase.”

“When glucose was added to saliva in the presence of fluoride there was a much greater inhibition of metabolism under anaerobic than aerobic conditions.”

“In the presence of fluoride , the conversion of fructose to glucose is inhibited, and an acid-labile phosphate ester accumulates.”

“Phosphate, fluoride , sulfate and all organic acid anions increased the decomposition rate of glucose and fructose by 23-2781%, but lowered the selectivity for 5-HMF from 36% to 100% as compared to the results without added salts.”