supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ Fluoride caused a concentration‐dependent decline in forskolin‐induced Cl– secretion and transepithelial resistance of Caco‐2 cell monolayers, with an IC50 for fluoride of about 3 mM for both parameters.”
The effect of fluoride on the structure, function, and proteome of intestinal epithelia“Phospholipase C activation by fluoride was inhibited by dibutyryl cyclic AMP and by agents that increase cyclic AMP levels such as iloprost and forskolin.”
“Corticotropin does not affect the affinity of AC for forskolin whereas fluoride increases this affinity, thus augmenting forskolin's potency.”
Analysis of effects of corticotropin, forskolin and fluoride on activity of adenylate cyclase of bovine adrenal cortex.“ Forskolin (10 microM) also significantly inhibited the activities induced by PGE1, GTP, and F-.”
“In hepatocytes and AH66 cells, forskolin and other adenylate cyclase activators such as PGE1, GTP, Gpp(NH)p, F- , and Mn2+ synergistically increased the enzyme activity.”
“ [3H]Forskolin binding to brain sections is displaced potently by forskolin (KD approximately equal to 15 nM) and is enhanced by fluoride and GTP analogs, agents which activate the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs.”
“ Forskolin stimulation is additive with that of guanyl nucleotides and F-.”
“The basal activity and the isoproterenol-, cholera toxin-, fluoride- or GppNHp-stimulated activities were maximally depressed by 10 microM forskolin (30-70% inhibition, EC50 = 0.3-0.5 microM).”
Forskolin inhibition of cyclic AMP generation in J774 macrophages.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback