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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Fluorides
Research Papers that Mention the Interaction
“ Fluorides appear to mediate their actions through the MAPK signaling pathway and can lead to changes in gene expression, cell stress , and cell death.”
Fluoride’s Effects on the Formation of Teeth and Bones, and the Influence of Genetics“In summary, this study proved that fluoride under certain dose can induce ER stress and promote Nrf2 nuclear import via PERK activation and suggested that antioxidation mechanism mediated by PERK-Nrf2 can alleviate fluoride-induced ER stress effectively.”
Effect of fluoride on PERK-Nrf2 signaling pathway in mouse ameloblasts“ Fluoride induces cell stress , including endoplasmic reticulum stress and oxidative stress, which leads to impairment of ameloblasts responsible for dental enamel formation.”
“High concentrations of fluoride induced ERS and osteoblast apoptosis in vivo.”
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