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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Fluorides
drug:
Aldesleukin
Research Papers that Mention the Interaction
“ Fluoride exposure induced cell cycle arrest of splenocytes and decreased the mRNA expression of IL-2 , which indicated compromised baseline lymphocyte proliferation in the spleen.”
Developmental fluoride exposure influenced rat's splenic development and cell cycle via disruption of the ERK signal pathway.“The addition of stannous fluoride suppressed production of TNF-a, IFN-g, IL12p70, IL10, IL-1b, IL2 , and IL-6, and also increased secretion of Il-8 in dose response fashion.”
“With damage to the splenocyte structure and DNA, the protein expression levels of IL-1β, IL-2 , IL-6, and TNF-α were significantly downregulated by exposure to fluoride.”
Induction of pathological changes and impaired expression of cytokines in developing female rat spleen after chronic excess fluoride exposure“Levels of IL-2 , TNF-α, and IL-1β in the supernatant markedly decreased when cells were exposed to fluoride at concentrations of 1 mmol/L or higher.”
Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells
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