supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago
drug:
Flunitrazepam
supplement:
Progesterone
Research Papers that Mention the Interaction
“Estradiol benzoate (2 µg) prevented the potentiation of flunitrazepam binding by NaCl in nonstressed and stressed animals, whereas progesterone (0.5 mg) increased the NaCl-induced potentiation of flunitrazepam binding in both nonstressed and stressed animals.”
Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor“In vivo administration of the sex steroids estradiol and progesterone induced a significant change in [3H]flunitrazepam (benzodiazepine agonist) binding levels in the amygdala, and cortico and posterior brain nuclei of the female rat.”
“The administration of 4 mg of progesterone , but not 1 mg, increased the binding of [3H]flunitrazepam in the basolateral amygdaloid nucleus and in the oriens-pyramidalis CA1 layer of the hippocampus.”
“In vivo progesterone enhanced flunitrazepam binding in the substantia gelatinosa while 10(-8) M progesterone in vitro was without effect.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback