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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Flunitrazepam
supplement:
Progesterone
Research Papers that Mention the Interaction
“Estradiol benzoate (2 µg) prevented the potentiation of flunitrazepam binding by NaCl in nonstressed and stressed animals, whereas progesterone (0.5 mg) increased the NaCl-induced potentiation of flunitrazepam binding in both nonstressed and stressed animals.”
Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor“In vivo administration of the sex steroids estradiol and progesterone induced a significant change in [3H]flunitrazepam (benzodiazepine agonist) binding levels in the amygdala, and cortico and posterior brain nuclei of the female rat.”
“In vivo progesterone enhanced flunitrazepam binding in the substantia gelatinosa while 10(-8) M progesterone in vitro was without effect.”
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