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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Flunitrazepam
supplement:
NAD
Research Papers that Mention the Interaction
“All the studied benzodiazepines (phenazepam, nitrazepam, clonazepam, flunitrazepam ) are able to displace [14C] NAD from its receptor sites, the mixed type of inhibition being manifested.”
[Effect of benzodiazepines on NAD binding to synaptic membrane in the rat brain].“It was shown that nicotinamide and NAD inhibit the specific binding of [3H]flunitrazepam to benzdiazepine receptors without causing a direct influence of gamma-aminobutyric acid (GABA) receptors.”
“The Kd value for the membrane-bound benzdiazepine receptor is 2.9 nM. NAD inhibited the specific binding of [3H]flunitrazepam to the solubilized membrane preparation when used at concentrations by several orders of magnitude lower than that of nicotinamide.”
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