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Possible Interaction: Flunitrazepam and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

A benzodiazepine, flunitrazepam , only slightly (10%) potentiated the GABA action.
Amino Acids  •  2004  |  View Paper
Full benzodiazepine agonists flunitrazepam (1 microM) and zolpidem (10 microM) significantly potentiated the response to 10 microM GABA by 124+/-15% (n=7) and 117+/-23% (n=3), respectively.
European journal of pharmacology  •  1998  |  View Paper
In the presence of … gamma-aminobutyric acid GABA ) the … diazepam, flunitrazepam and midazolam to inhibit [3H]flumazenil binding to the alpha 1-construct were increased 3 to 5 fold, whereas …,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate methyl ester a 2.5-fold reduction in potency was observed.
European journal of pharmacology  •  1993  |  View Paper
FNTZ , a well known GABA modulator, could also potentiate the effect of GABA.
Molecular membrane biology  •  1999  |  View Paper
Thus flunitrazepam increased the duration of sIPSCs and potentiated the amplitude of currents evoked by pressure application of GABA.
Journal of neurophysiology  •  1999  |  View Paper
Simultaneous treatment with flunitrazepam and GABA did not produce an additive down-regulation of alpha 1 subunit protein, but produced an effect of the same magnitude as that of flunitrazepam alone.
This down-regulation induced by the combination of flunitrazepam and GABA was inhibited by flumazenil (78%), but unaffected by bicuculline.
This study has shown that both flunitrazepam and GABA treatment, via their respective binding sites, caused a reduction in the expression of the GABAA receptor alpha 1 subunit protein; an effect mediated through the same neurochemical mechanism.
British journal of pharmacology  •  1996  |  View Paper
GABA produced a dose-dependent stimulation of flunitrazepam binding in all age groups, but the maximum stimulation in aged animals was significantly higher (24%) than in young and mature animals.
The decline of flunitrazepam binding sites and the high sensitivity of flunitrazepam binding to regulation by GABA in aged animals were reversed by 8 to 10 weeks of endurance exercise.
Neurobiology of Aging  •  1995  |  View Paper
Lindane was found to be toxic to the neurons, an effect that could be completely prevented by the simultaneous presence of GABA (0.1 microM) and flunitrazepam (100 microM) and reduced by GABA alone.
Journal of neuroscience research  •  1994  |  View Paper
Flunitrazepam also produced a greater shift to the left of the GABA concentration-response curve with alpha 3 beta 1 gamma 2L than with alpha 1 beta 1 gamma 2L.
Flunitrazepam potentiated control GABA responses to a maximum of 77% with alpha 1 beta 1 gamma 2L and 105% with alpha 3 beta 1 gamma 2L, with EC50 values of 29 +/- 11 nM and 23 +/- 10 nM, respectively.
Molecular pharmacology  •  1993  |  View Paper
Flunitrazepam produced a parallel leftward shift of GABA concentration-response curves on alpha 1,beta 1,gamma 2L cells.
British journal of pharmacology  •  1993  |  View Paper
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