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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Flunitrazepam
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“In the presence of … gamma-aminobutyric acid GABA ) the … diazepam, flunitrazepam and midazolam to inhibit [3H]flumazenil binding to the alpha 1-construct were increased 3 to 5 fold, whereas …,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate methyl ester a 2.5-fold reduction in potency was observed.”
Expression and properties of recombinant alpha 1 beta 2 gamma 2 and alpha 5 beta 2 gamma 2 forms of the rat GABAA receptor.“It was shown that the binding of [3H] flunitrazepam to membrane preparations is enhanced in the presence of GABA.”
“ Flunitrazepam , a benzodiazepine agonist which potentiates GABA responses in both neurons and astrocytes was only effective in receptors containing the gamma 2 subunit (alpha 1 beta 1 gamma 2 and alpha 5 beta 1 gamma 2).”
“The addition of GABA to the incubation medium resulted in an increase of [3H]flunitrazepam binding , suggesting the coupling of these sites to a GABAA receptor.”
“ GABA enhanced the affinity of [3H]-flunitrazepam and [3H]-diazepam, but not that of [3H]-Ro 15-1788 and [3H]-methyl-beta-carboline 3-carboxylate for their specific binding sites as well in cerebral as in cerebellar human cortex.”
“ GABA enhanced [3H]flunitrazepam binding in both the HD and control SN by increasing the affinity of BDZ receptors for [3H]flunitrazepam.”
“Maximal stimulation of [3H] flunitrazepam binding by GABA was decreased in the cerebral cortex and the EC50-value for the GABA stimulation increased in the hippocampus in the EOS rats at the age of 4 months.”
Neonatal administration of a GABA-T inhibitor alters central GABAA receptor mechanisms and alcohol drinking in adult rats“ FNTZ , a well known GABA modulator, could also potentiate the effect of GABA.”
“Thus flunitrazepam increased the duration of sIPSCs and potentiated the amplitude of currents evoked by pressure application of GABA.”
“6 This study has shown that both flunitrazepam and GABA treatment, via their respective binding sites, caused a reduction in the expression of the GABAA receptor α1 subunit protein; an effect mediated through the same neurochemical mechanism.”
“This down‐regulation induced by the combination of flunitrazepam and GABA was inhibited by flumazenil (78%), but unaffected by bicuculline.”
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