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Last Updated: 3 years ago

Possible Interaction: Flunitrazepam and Adrenocorticotropic Hormone

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drug:

Flunitrazepam

supplement:

Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

“ Flunitrazepam , a benzodiazepine that binds with high nanomolar affinity to MBR, was recently shown to act as an antagonist of ACTH and LH/hCG-induced steroidogenesis and was found in the present studies to inhibit DBI-stimulated mitochondrial steroidogenesis.”

Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors.

Endocrinology • 1991 | View Paper

“These ACTH fragments also inhibited GABA-stimulated [3H] FNP binding.”

Interactions of ACTH4–10 and ACTH1–24 with L-[3H] glutamate binding sites and GABA/benzodiazepine/picrotoxin receptor complexes in vitro

Brain and Development • 1988 | View Paper

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