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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Flunarizine and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Drugs suggested to affect membrane properties, such as chlorpromazine, was without effect at 1 or 10 microM, whereas flunarizine (FLU) at 1 microM inhibited both L-C (24%) and GABA uptake (17%).
Pharmacological research  •  1996  |  View Paper
Additionally, 10 microM flunarizine directly antagonises ouabain-induced tetrodotoxin (TTX)-sensitive Na+ influx, glutamate, aspartate and GABA release from synaptosomes, whilst inhibiting veratridine-induced Ca(2+)-independent TTX-sensitive Na+ influx and glutamate release at 15 microM and 10 microM in cells and synaptosomes, respectively.
Brain Research  •  1993  |  View Paper