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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Flunarizine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Calcium and the calcium overload blocker flunarizine exert profound effects on mood.”
Effect of flunarizine and calcium on serotonin uptake in human and rat blood platelets and rat synaptosomes“This was in contrast to flunarizine , which showed a protective effect only in combination with calcium.”
“The antivasoconstrictor activity of the drugs cinnarizine and flunarizine is considered in relation to their inhibitory action on calcium ion flux mechanisms.”
“Increasing concentrations of flunarizine , a calmodulin antagonist, in a concentration-dependent way blocks binding between calcium and calmodulin, and at the same time leads to the shift of concentration-effect curves for serotonin to the right and a decrease of maximum reaction.”
Role of calcium and calmodulin in reaction of gastric fundus contraction.“ Flunarizine (5 min incubation followed 1 min wash-out) reduced the amplitude of the high-potassium induced calcium increase in a dose-dependent manner (Kd = 370 ± 100 nmol/l; mean ± SEM; n = 8), causing complete inhibition at a concentration of 10 μmol/1 in the majority of cells.”
“ Flunarizine (≥ 1 μmol/1) caused a reversible increase of the resting level of intracellular calcium in some cells, an effect which disappeared in the absence of extracellular calcium.”
“Nifedipine, flunarizine , and betaxolol all reduced the NMDA-induced influx of calcium into the isolated retina or cortical neurons, but betaxolol was the least effective.”
“The neuroprotective action of flunarizine is to reduce the influx of calcium and sodium into stressed neurons.”
“ Flunarizine reduced the increase of lactate in blood, ameliorated the depletion of ATP stores in tissues, and prevented the calcium accumulation in heart and liver.”
“In contrast to R56865, flunarizine blocked both types of Ca2+ channel in a use-dependent manner.”
“The calcium antagonist, flunarizine , has been shown to suppress the accumulation of intracellular calcium and has been proposed to protect against triggered activity due to calcium overload.”
“While in HCM there is no difference among the three drugs, FLU and VER had a stronger effect on cell growth inhibition in LCM.”
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