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Possible Interaction: Flunarizine and Calcium Supplement

Research Papers that Mention the Interaction

This was in contrast to flunarizine , which showed a protective effect only in combination with calcium.
Neuroscience Letters  •  1987  |  View Paper
The antivasoconstrictor activity of the drugs cinnarizine and flunarizine is considered in relation to their inhibitory action on calcium ion flux mechanisms.
Angiology  •  1979  |  View Paper
Both adenosine and flunarizine prevent Ca++ influx into activated neutrophils as detected by the fluorescent Ca++ chelator Quin-2.
Experimental Gerontology  •  1990  |  View Paper
At pH 11 less than 20% of Ca could be displaced by flunarizine.
The Ca displacing properties of charged flunarizine may prevent a deleterious phospholipid reorientation within the membrane induced by the intracellular Ca rise during ischemia.
Biochemical pharmacology  •  1988  |  View Paper
Increasing concentrations of flunarizine , a calmodulin antagonist, in a concentration-dependent way blocks binding between calcium and calmodulin, and at the same time leads to the shift of concentration-effect curves for serotonin to the right and a decrease of maximum reaction.
Postepy higieny i medycyny doswiadczalnej  •  2011  |  View Paper
Flunarizine (5 min incubation followed 1 min wash-out) reduced the amplitude of the high-potassium induced calcium increase in a dose-dependent manner (Kd = 370 ± 100 nmol/l; mean ± SEM; n = 8), causing complete inhibition at a concentration of 10 μmol/1 in the majority of cells.
Flunarizine (≥ 1 μmol/1) caused a reversible increase of the resting level of intracellular calcium in some cells, an effect which disappeared in the absence of extracellular calcium.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Flunarizine , a non-selective blocker of voltage-dependent Ca2+ and Na+ channels, is clinically effective against several neurological disorders, including epilepsy, migraine, and alternating hemiplegia of childhood.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Nifedipine, flunarizine , and betaxolol all reduced the NMDA-induced influx of calcium into the isolated retina or cortical neurons, but betaxolol was the least effective.
Nifedipine, flunarizine , and betaxolol all reduced the NMDA-induced influx of calcium into the isolated retina or cortical neurons, but betaxolol was the least effective.
The neuroprotective action of flunarizine is to reduce the influx of calcium and sodium into stressed neurons.
Investigative ophthalmology & visual science  •  2002  |  View Paper
Dotarizine … flunarizine also inhibited … whole-cell Ca2+ and Ba2+ currents (ICa, IBa) in voltage-clamped chromaffin cells, induced by depolarizing test pulses to 0 mV, during 50 ms, from a holding potential of -80 mV. Blockade exhibited IC50s of 4 microM for dotarizine and 2.2 microM for flunarizine.
British journal of pharmacology  •  1995  |  View Paper
The depolarization-induced increase in intrasynaptosomal free cytosolic calcium concentration is also inhibited by flunarizine , a calcium antagonist that has protective effects in animal models of cerebral anoxia and ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  •  1993  |  View Paper
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