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Last Updated: 3 years ago
drug:
Flumazenil
supplement:
Melatonin
Research Papers that Mention the Interaction
“In this double-blind, placebo-controlled study we investigated whether 10 mg flumazenil , a pure benzodiazepine antagonist, can block the hypnotic and hypothermic effects of 3 mg melatonin.”
“Polysomnographic recordings and core body temperature recordings revealed that melatonin , either in combination with placebo or with flumazenil , significantly increased the amounts of sleep, and decreased core body temperature in comparison with placebo alone or the combination of flumazenil plus placebo.”
Hypnotic and hypothermic effects of melatonin on daytime sleep in humans: lack of antagonism by flumazenil“Although melatonin is not regulated as a drug, it may interact with benzodiazepines, be antagonized by naloxone and flumazenil , and interact with melatonin receptors in the central nervous system and elsewhere in the body.”
“The antiallodynic effect of MT was also abolished by flumazenil and picrotoxin.”
Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.“ Flumazenil (0.5 mg/kg) and picrotoxin (0.5 mg/kg) pretreatments with a lower dose of melatonin (5 mg/kg) significantly antagonized the protective effect of melatonin.”
“Potentiation of pentobarbitone sleeping time by diazepam (1 mg/kg IP), but not melatonin (10 mg/kg IP), was blocked by pretreatment with the benzodiazepine antagonist, flumazenil (10 mg/kg IP).”
“The inhibition of U50 tolerance by melatonin was reversed by flumazenil and picrotoxin treatment, suggesting that benzodiazepine-GABAAergic mechanisms play an important role in the development of tolerance to U50 analgesia and that melatonin inhibits the development of U50 tolerance via benzodiazepine-GABAAergic mechanisms.”
“The inhibition of U50 tolerance by melatonin was reversed by the chronic treatment with flumazenil (0.1 mg/kg), a benzodiazepine receptor antagonist and picrotoxin (1 mg/kg), a GABAA-gated chloride channel blocker.”
“A significant interaction was shown between melatonin and flumazenil or picrotoxin.”
“Whereas, flumazenil failed to reverse the anti-depressant action of melatonin , thereby suggesting that central BZ receptor were not involved in its action.”
“Moreover, flumazenil was able to counteract, in a dose-dependent manner, the anxiolytic activity of melatonin in BALB/c, suggesting involvement of central GABAergic system in the pharmacological effects of melatonin.”
“ Flumazenil , a central acting benzodiazepine antagonist, slightly reduced melatonin secretion.”
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