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Last Updated: 2 months ago

Possible Interaction: Flumazenil and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

In this double-blind, placebo-controlled study we investigated whether 10 mg flumazenil , a pure benzodiazepine antagonist, can block the hypnotic and hypothermic effects of 3 mg melatonin.
Polysomnographic recordings and core body temperature recordings revealed that melatonin , either in combination with placebo or with flumazenil , significantly increased the amounts of sleep, and decreased core body temperature in comparison with placebo alone or the combination of flumazenil plus placebo.
Neuroscience Letters  •  1996  |  View Paper
Although melatonin is not regulated as a drug, it may interact with benzodiazepines, be antagonized by naloxone and flumazenil , and interact with melatonin receptors in the central nervous system and elsewhere in the body.
Southern medical journal  •  1997  |  View Paper
The antiallodynic effect of MT was also abolished by flumazenil and picrotoxin.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2012  |  View Paper
A combination of flumazenil (0.5 mg/kg, ip) and picrotoxin (0.5 mg/kg, ip) with lower dose of melatonin (5 mg/kg, ip) significantly antagonized the protective effect of melatonin.
Indian journal of experimental biology  •  2011  |  View Paper
Flumazenil (0.5 mg/kg) and picrotoxin (0.5 mg/kg) pretreatments with a lower dose of melatonin (5 mg/kg) significantly antagonized the protective effect of melatonin.
Fundamental & clinical pharmacology  •  2009  |  View Paper
Potentiation of pentobarbitone sleeping time by diazepam (1 mg/kg IP), but not melatonin (10 mg/kg IP), was blocked by pretreatment with the benzodiazepine antagonist, flumazenil (10 mg/kg IP).
Psychopharmacology  •  2005  |  View Paper
The inhibition of U50 tolerance by melatonin was reversed by flumazenil and picrotoxin treatment, suggesting that benzodiazepine-GABAAergic mechanisms play an important role in the development of tolerance to U50 analgesia and that melatonin inhibits the development of U50 tolerance via benzodiazepine-GABAAergic mechanisms.
The inhibition of U50 tolerance by melatonin was reversed by the chronic treatment with flumazenil (0.1 mg/kg), a benzodiazepine receptor antagonist and picrotoxin (1 mg/kg), a GABAA-gated chloride channel blocker.
Pharmacology Biochemistry and Behavior  •  2004  |  View Paper
A significant interaction was shown between melatonin and flumazenil or picrotoxin.
Pharmacology Biochemistry and Behavior  •  2003  |  View Paper
Whereas, flumazenil failed to reverse the anti-depressant action of melatonin , thereby suggesting that central BZ receptor were not involved in its action.
European Neuropsychopharmacology  •  2000  |  View Paper
Moreover, flumazenil was able to counteract, in a dose-dependent manner, the anxiolytic activity of melatonin in BALB/c, suggesting involvement of central GABAergic system in the pharmacological effects of melatonin.
Pharmacology Biochemistry and Behavior  •  1999  |  View Paper
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