Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Flumazenil and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

INTRODUCTION Flumazenil antagonizes the effects of benzodiazepines at gamma-aminobutyric acid (GABA) type A receptors in the central nervous system.
Journal of pharmacological and toxicological methods  •  2001  |  View Paper
γ-amino butyric acid GABA ) modulation with GABAA receptor agonists clarithromycin and flumazenil may help daytime somnolence.
Nature and science of sleep  •  2017  |  View Paper
In vitro experiments in human embryonic kidney-293T cells demonstrated that flumazenil inhibited isoflurane-mediated GABA current enhancement (n = 34 cells, 88.7 ± 2.42% potentiation at 3 μM).
Anesthesiology  •  2016  |  View Paper
The increase of GABA in the hippocampus and cerebellum was antagonized by the administration of flumazenil.
European journal of pharmacology  •  2006  |  View Paper
reduced GABA outflow and caused the expected behavioral effects (reduced muscle tone, mild 5-HT syndrome) which were prevented by the respective, selective antagonists, flumazenil (1mg/kg, i.p.)
Neurochemistry International  •  2003  |  View Paper
Flumazenil augmented 10(-6)mol l(-1) GABA effects, while picrotoxin and flumazenil abolished the effects of 5 x 10(-4)mol l(-1) GABA.
GABA decreased QO(2) in concentrations of 5 x 10(-4), 10(-2) and 5 x 10(-2)mol l(-1), while 10(-5) and 10(-6)mol l(-1) GABA had no effect, as well as diazepam, flumazenil and picrotoxin.
Pharmacological research  •  2002  |  View Paper
Finally, the hypothesis that altering GABA tone would change the efficacy of Flumazenil from a neutral antagonist to an inverse agonist was tested on limbic transmission.
Journal of psychopharmacology  •  2000  |  View Paper
Flumazenil competitively blocks the pharmacological effects of both positive and negative allosteric modulators acting at the benzodiazepine binding sites of gamma-aminobutyric acid (GABA(A)) receptors.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
At a high concentration (10 microM), flumazenil was a weak potentiator of the GABA response.
Molecular pharmacology  •  1996  |  View Paper
Diazepam activity is enhanced by simultaneous GABA administration and it is suppressed by the specific antagonist flumazenil.
Life sciences  •  1995  |  View Paper
Show More