Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Flumazenil and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

Flumazenil , an imidazobenzodiazepine derivative, antagonizes the hypnotic/sedative effects of benzodiazepines on γ-aminobutyric acid receptors.
European journal of anaesthesiology  •  2010  |  View Paper
INTRODUCTION Flumazenil antagonizes the effects of benzodiazepines at gamma-aminobutyric acid (GABA) type A receptors in the central nervous system.
Journal of pharmacological and toxicological methods  •  2001  |  View Paper
MF1-promoted GABA currents were blocked by flumazenil (10 μm) treatment, suggesting that MF1 enhances receptor function via the benzodiazepine recognition site.
International journal of molecular sciences  •  2020  |  View Paper
In the two animal models of seizures, the … IF (25, 50 and 75 mg/kg) with flumazenil blocked the anticonvulsant effect, suggesting that the mechanism of action of this ester derived of … may be related to activity in the benzodiazepine-binding site of the GABAA receptor ( γ-aminobutyric acid, …).
Chemico-biological interactions  •  2015  |  View Paper
The increase of GABA in the hippocampus and cerebellum was antagonized by the administration of flumazenil.
European journal of pharmacology  •  2006  |  View Paper
Flumazenil augmented 10(-6)mol l(-1) GABA effects, while picrotoxin and flumazenil abolished the effects of 5 x 10(-4)mol l(-1) GABA.
GABA decreased QO(2) in concentrations of 5 x 10(-4), 10(-2) and 5 x 10(-2)mol l(-1), while 10(-5) and 10(-6)mol l(-1) GABA had no effect, as well as diazepam, flumazenil and picrotoxin.
Pharmacological research  •  2002  |  View Paper
Finally, the hypothesis that altering GABA tone would change the efficacy of Flumazenil from a neutral antagonist to an inverse agonist was tested on limbic transmission.
Journal of psychopharmacology  •  2000  |  View Paper
gamma-aminobutyric acid … ( flumazinil ) from membranes of pigeon cerebrum, and ranged from full agonist-like efficacy (Ro 19-5470; 7-(3-cyclopropyl-1,2,4-oxodiazol-5-…; 7-chloro-4,5-dihydro-3-(3-hydroxy-1-propynyl)-5-methyl-6H-imidazo[1,5-a] -[1,4 ]benzodiazepine-6-one).
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
Flumazenil competitively blocks the pharmacological effects of both positive and negative allosteric modulators acting at the benzodiazepine binding sites of gamma-aminobutyric acid (GABA(A)) receptors.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
Diazepam activity is enhanced by simultaneous GABA administration and it is suppressed by the specific antagonist flumazenil.
Life sciences  •  1995  |  View Paper
Show More