Possible Interaction: Flufenamic Acid and Calcium Supplement

“Three TAS2R14 agonists, flufenamic acid , chlorhexidine, and diphenhydramine, also evoked rises in intracellular calcium in TCL.”

“ Flufenamic acid commonly not only affects non-selective cation channels and chloride channels, but also modulates potassium, calcium and sodium channels with effective concentrations ranging from 10(-6)M in TRPM4 channel inhibition to 10(-3)M in two-pore outwardly rectifying potassium channel activation.”

“The two fenamates inhibited the increases in intracellular free calcium concentration induced by either the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine or the calcium ionophore A23187 in fura-2-labeled PMNs.”

“It requires an increase in postsynaptic calcium for activation, and is blocked by flufenamic acid , an antagonist of a previously identified calcium activated non-selective cation channel (I(CAN)).”

“In mouse olfactory epithelium, we found that >80% of the summated electrical response to odors is blocked by niflumic acid or flufenamic acid , each of which inhibits Ca2+ -activated Cl- channels in ORNs.”

“In contrast flufenamic acid (100 μM), an inhibitor of non‐selective cation channels, genistein (10 μM), a broad‐range tyrosine kinase inhibitor, and piceatannol (10 μM), an inhibitor specific for non‐receptor Syk tyrosine kinase, inhibited CCE during ACh decay but not during Ca2+ reintroduction.”

“It was concluded that flufenamic acid was affecting calcium movements across the mitochondrial membrane by virtue of its ability to uncouple oxidative phosphorylation.”

“The anti-inflammatory agent flufenamic acid was found to inhibit calcium uptake in isolated mitochondria at low concentrations (IC50 = 7.2 microM).”