Possible Interaction: Fluconazole and Vitamin C

“In addition, checkerboard microdilution assay showed that addition of antioxidant ascorbic acid or reduced glutathione reduced the synergistic antifungal activity of FLC + BBR significantly.”

“4 Intragastric administration of AA (50 or 500 mg/kg) significantly decreased the antifungal effect of 0.5 mg/kg FCZ.”

“5 In vitro, AA decreased the activity of FCZ against various Candida strains.”

“6 The results of the present study indicate that AA inhibits the antifungal activity of FCZ , suggesting that the two should not be used together clinically for the treatment of candidiasis.”

“administration of AA (50 or 500 mg/kg) had no significant effect on the survival of mice, it dose‐dependently inhibited the activity of FCZ , with significant inhibition observed with 500 mg/kg AA.”

“Recent studies have implied that the antifungal drug fluconazole (FLC) can induce oxidative stress in C. neoformans by increasing the production of reactive oxygen species (ROS), as presence of the antioxidant ascorbic acid (AA) could reverse the inhibitory effects of FLC on C. neoformans.”

“Addition of ascorbic acid (AA), an anti-oxidant at 10 mM, reduced the inhibitory effects of FLC.”

“Conclusions: Unlike to what happens in treatment of bacterial infection, AA should not be used together with Flu in the treating oral mucositis caused by Candida.”