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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Fluconazole and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

In addition, checkerboard microdilution assay showed that addition of antioxidant ascorbic acid or reduced glutathione reduced the synergistic antifungal activity of FLC + BBR significantly.
Journal of proteome research  •  2009  |  View Paper
Recent studies have implied that the antifungal drug fluconazole (FLC) can induce oxidative stress in C. neoformans by increasing the production of reactive oxygen species (ROS), as presence of the antioxidant ascorbic acid AA ) could reverse the inhibitory effects of FLC on C. neoformans.
BMC Microbiology  •  2019  |  View Paper
Addition of ascorbic acid (AA), an anti-oxidant at 10 mM, reduced the inhibitory effects of FLC.
PloS one  •  2018  |  View Paper
CONCLUSIONS Unlike to what happens in treatment of bacterial infection, AA should not be used together with Flu in the treating oral mucositis caused by Candida.
CONCLUSIONS Unlike to what happens in treatment of bacterial infection, AA should not be used together with Flu in the treating oral mucositis caused by Candida.
Therapeutic advances in infectious disease  •  2017  |  View Paper
In vitro, AA decreased the activity of FCZ against various Candida strains.
Intragastric administration of AA (50 or 500 mg/kg) significantly decreased the antifungal effect of 0.5 mg/kg FCZ.
The results of the present study indicate that AA inhibits the antifungal activity of FCZ , suggesting that the two should not be used together clinically for the treatment of candidiasis.
administration of AA (50 or 500 mg/kg) had no significant effect on the survival of mice, it dose-dependently inhibited the activity of FCZ , with significant inhibition observed with 500 mg/kg AA.
Clinical and experimental pharmacology & physiology  •  2009  |  View Paper