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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Fluconazole and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

An evaluation of IC50's versus in vivo Cmax values suggests that inhibitors such as clotrimazole or fluconazole may interact with CYP26 at clinically relevant concentrations and may alter levels of retinoic acid.
Journal of enzyme inhibition and medicinal chemistry  •  2016  |  View Paper
Here, the authors report a case of APL who developed acute renal failure during ATRA and concurrent use of fluconazole.
Triazole derivatives such as fluconazole inhibit the NADPH-dependent cytochrome P-450-mediated catabolism of ATRA and are increased plasma levels of ATRA.
Pediatric hematology and oncology  •  2008  |  View Paper
We report a case of a patient with ATRA toxicity thought to be secondary to interaction with fluconazole.
Journal of pediatric hematology/oncology  •  2003  |  View Paper
Fluconazole inhibited the NADPH-dependent cytochrome P450-mediated catabolism of trans-retinoic acid in a concentration-dependent manner.
Since fluconazole is a well-tolerated agent frequently administered to leukemia patients, its use in combination with trans-retinoic acid merits further consideration.
Biochemical pharmacology  •  1995  |  View Paper
Expression of Hox-b1 and Krox20 (markers of specific rhombomeres) was altered after FLUCO and RA exposure.
Furthermore, FLUCO and RA showed a synergistic effect.
Reproductive toxicology  •  2004  |  View Paper