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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Fluconazole
supplement:
Tretinoin
Research Papers that Mention the Interaction
“An evaluation of IC50’s versus in vivo Cmax values suggests that inhibitors such as clotrimazole or fluconazole may interact with CYP26 at clinically relevant concentrations and may alter levels of retinoic acid.”
Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases“Here, the authors report a case of APL who developed acute renal failure during ATRA and concurrent use of fluconazole.”
“Triazole derivatives such as fluconazole inhibit the NADPH-dependent cytochrome P-450-mediated catabolism of ATRA and are increased plasma levels of ATRA.”
“We report a case of a patient with ATRA toxicity thought to be secondary to interaction with fluconazole.”
“I suggest that high-dose fluconazole leads to increased levels of endogenous retinoids and that this factor may explain, at least in part, the reversible hair loss, dry skin, and dry lips associated with fluconazole.”
“ Fluconazole inhibited the NADPH-dependent cytochrome P450-mediated catabolism of trans-retinoic acid in a concentration-dependent manner.”
“Since fluconazole is a well-tolerated agent frequently administered to leukemia patients, its use in combination with trans-retinoic acid merits further consideration.”
“Expression of Hox-b1 and Krox20 (markers of specific rhombomeres) was altered after FLUCO and RA exposure.”
“Furthermore, FLUCO and RA showed a synergistic effect.”
Relationship between hindbrain segmentation, neural crest cell migration and branchial arch abnormalities in rat embryos exposed to fluconazole and retinoic acid in vitro.
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