Possible Interaction: Fluconazole and Sphingosine 1-Phosphate

“ FLCZ exhibits potent antifungal activities against Candida spp.,”

“However, the wide use of fluconazole as a first-line antifungal therapy has led to the development of resistance in clinical isolates of Candida species including Candida albicans and the emerging non-albicans Candida spp.”

“There was a moderate correlation between the fluconazole MICs for Candida spp.”

“Consistent with previous studies from China, resistance to fluconazole is prominent among Candida spp.”

“Administration of fluconazole was a protective factor for both Candida spp.”

“Azole agents overuse, especially fluconazole , for the treatment and prophylaxis of fungal infections has put selective pressure on Candida spp.”

“Our results demonstrated that exposure to fluconazole reduces Candida spp.”

“These results also suggest that adhesion, even in non‐albicans species, could be factors that, along with predisposing conditions … to the host, determine if an individual will develop disease or remain as a healthy carrier and confirm that fluconazole has an impact in the adherence ability in Candida spp.”

“Either fluconazole or voriconazole MIC results may serve as surrogate markers to predict the susceptibility of Candida spp.”

“The present study addresses the use of fluconazole as a surrogate marker to predict the susceptibility of Candida spp.”

“ Fluconazole may serve as a surrogate marker to predict the susceptibility of Candida spp.”

“The present study addresses the issue of cross-resistance between fluconazole and ravuconazole and the use of fluconazole as a surrogate marker to predict the susceptibility of Candida spp.”