“ ISO at non‐antifungal concentration interacts synergistically with amphotericin B (AMB) and fluconazole (FLC), but the combination with flucytosine (5‐FC) showed no interaction.”
“ ISO combined with FLC caused metacaspase activation and DNA condensation, markers of apoptosis, higher than the combination with ISO/AMB.”
“In conclusion, AMB and FLC enhanced the antifungal potency of ISO through oxidative stress when used in synergy.”