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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Floxuridine
supplement:
Folate
Research Papers that Mention the Interaction
“This reduced folate enhanced the cytotoxicity and the growth inhibitory potency of 5-fluorouracil ( 5-FUra ) and of 5-fluoro-2'-deoxyuridine (FUdR) against all cell lines examined.”
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.“The lack of sufficient folates in the tumor cell, especially N5,N10-methylene tetrahydrofolate, would thus result in less than optimal cell kill by FUdR and possibly by 5-FU.”
“These results demonstrate that folate metabolism is important for the efficacy of FdUrd.”
Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell Lines
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