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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Flecainide
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“ Sodium bicarbonate in larger doses has been reported to stabilise patients with flecainide intoxication due to modification of the binding of flecainide to sodium receptors in cardiomyocytes, and due to alkalisation which makes flecainide detach from sodium receptors.”
A somnolent woman in her fifties with acute circulatory failure.“1M sodium bicarbonate may be useful in assessing the role of sodium channel inhibition in mediating the toxicity of flecainide or other Class IC drugs.”
Hypertonic sodium bicarbonate partially reverses QRS prolongation due to flecainide in rats.“While extracorporeal support is often required following flecainide ingestion, we present two cases where it was avoided due to aggressive multimodal management with sodium bicarbonate , electrolyte repletion, and 20% intravenous lipid emulsion.”
Flecainide Toxicity Secondary to Accidental Overdose: A Pediatric Case Report of Two Brothers
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