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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Flecainide and Sodium Bicarbonate

Research Papers that Mention the Interaction

Sodium bicarbonate in larger doses has been reported to stabilise patients with flecainide intoxication due to modification of the binding of flecainide to sodium receptors in cardiomyocytes, and due to alkalisation which makes flecainide detach from sodium receptors.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke  •  2019  |  View Paper
1M sodium bicarbonate may be useful in assessing the role of sodium channel inhibition in mediating the toxicity of flecainide or other Class IC drugs.
Life sciences  •  1989  |  View Paper