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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Flecainide and Quinine



Research Papers that Mention the Interaction

This finding, in association with a fall in amount of the second, meta-O-dealkylated lactam metabolite (MODLF) recovered in its conjugated forms in the urine, suggests that quinine inhibits both the first and the second steps of the sequential metabolism of flecainide.
When the subjects received quinine in addition to flecainide , the PR interval in the ECG was slightly more prolonged than with flecainide alone.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
We also compared the inhibitory potency of FLEC with other Class I agents: quinidine ( QUIN , Class Ia); lignocaine (LIG, Class Ib) and propafenone (PROPAF, Class Ic).
British journal of pharmacology  •  2002  |  View Paper