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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Flecainide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Using isolation cell procedure and whole cell recording, we found that 10 μM quinidine (34.77±6.5%, n=5) and 0.5 μM flecainide (50.46±6.2%, n=4) decrease calcium current in human atrium.”
Differential effects of quinidine and flecainide on plateau duration of human atrial action potential“Both flecainide and pilsicainide decreased peak Ca2+i , peak tension, and peak ICa concentration dependently.”
Mechanisms of negative inotropic effects of class Ic antiarrhythmic agents: comparative study of the effects of flecainide and pilsicainide on intracellular calcium handling in dog ventricular myocardium.“3 Contractile responses induced by addition of Ca to Ca‐free high‐K solution were also dose‐dependently inhibited by flecainide (IC50 = 2.5 ± 0.3 × 10−5 m).”
“6 These results indicated that in rat isolated aortae, caudal arteries and portal veins, flecainide inhibited Ca entry through voltage‐operated channels and NA‐induced Ca uptake as well as Ca release from intracellular stores, thus decreasing the availability of intracellular free Ca required for vascular smooth muscle contraction.”
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