Possible Interaction: Flavone Acetic Acid and Aldesleukin

“ FAA stimulates NK cell activity, induces interferon α and synergises with interleukin 2 in the treatment of murine renal cancer.”

“Unexpectedly severe hypotension after the third FAA , when given 2-4 days after RIL-2 , was the major toxicity (8/15 grade 3 or 4).”

“A number of reports favour the hypothesis that FAA could behave as a biological response modifier; in fact FAA stimulates natural killer (NK) cells, induces secretion of type I interferon and synergizes with interleukin-2 to increase NK/lymphokine-activated killer (LAK) activity in vivo.”

“The accumulated data derived from a series of experiments also demonstrates that FAA synergizes with interleukin 2 (IL-2) for the treatment of murine renal cancer.”

“The immunomodulatory and immunotherapeutic effects of FAA are strictly dose dependent with doses of FAA greater than 150 mg/kg effectively synergizing with IL-2 , and doses less than 150 mg/kg exhibiting very little therapeutic effect.”

“The results demonstrate that FAA potently augments NK activity in the blood, spleen, and liver of Renca-bearing mice and that the administration of rIL-2 in addition to FAA results in a further augmentation of NK activity over that observed with FAA alone.”

“Therapeutic synergy between FAA and rIL-2 was observed against primary tumors, minimal residual disease, and experimental-induced pulmonary metastases.”