Possible Interaction: Fish Oils and Phospholipids

“ Fish oil supplementation increased LCn-3 PUFA in plasma and platelet phospholipids , decreased ADP-induced platelet aggregation, and increased plasma cholesterol.”

“The level of eicosapentaenoic acid in plasma phospholipids did not change with placebo supplementation, but was significantly increased with fish oil supplementation in both young male and elderly subjects (median increase 200%).”

“We found that platelet membrane phospholipids were uniformly affected by fish oil supplementation (P < 0.001) but with significant carry-over effects despite a 10 week wash-out period.”

“Dietary supplementation with fish oil resulted in a significant increase in EPA in neutrophil phospholipids that was greater in group L (mean 2.0 +/- 0.4%) than group H (mean 1.5 +/- 0.3%; P less than 0.005).”

“Although the fish oil supplemented diet produced a greater than 10 fold increase in the eicosapentaenoic acid content of neutrophil phospholipids , there was no significant change in airways responsiveness to histamine or any change in any of the clinical measurements.”

“ Fish oil feeding doubled the proportion of 20:5n-3 and 22:6n-3 in muscle phospholipids.”

“ Fish oil from S. longiceps brought maximum changes in level of neutral lipid composition in heart, and increased the concentration of phospholipid and decreased the activity of HMG-CoA reductase in comparison with the fish oil from R. kanagurta and C. batrachus.”

“Certain beneficial effects of fish oil may result from altered PG metabolism resulting from increases in the EPA/AA ratios of precursor phospholipids.”

“Relative to the baseline, fish oil supplementation increased phospholipid concentrations of EPA (+142%), DPA (+13%), and DHA (+22%) (P<0.001 each).”

“Conclusions/Significance In healthy subjects, fish oil supplementation alters lipid metabolism and increases the proportion of phospholipids and triglycerides containing long-chain polyunsaturated fatty acids.”