Possible Interaction: Fish Oils and Phosphatidylethanolamine

“ Fish oil supplementation led to a significant increase of 22∶5ω3 in PS and decreases of 20∶3ω6 in PC and 22∶4ω6 in PE.”

“A bolus of fish oil prevented declines in DHA of red cell phospholipids ( phosphatidylethanolamine , phosphatidylcholine, and phosphatidylserine) during 4 to 6 wk of feeding, with red blood cell DHA indistinguishable from that of infants fed human milk.”

“A marked increase in the relative EPA content of phosphatidylcholine (PC) and phosphatidylethanolamine PE ) was noted after 2 and 4 weeks fish oil supplementation.”

“ Fish oil reduced the AA in the old rat brains, diacyl and alkenylacyl 18:0/20:4 PE being most affected.”

“Feeding either FO or PO lowered the content of 20:4(n - 6) in hepatic phosphatidylethanolamine , whereas clofibric acid increased it.”

“Retinal phosphatidylethanolamine was even more sensitive to the impact of the fish oil diet, with DHA levels in newborn rabbits rising from 10% (control diet) to 43% of total fatty acids.”

“Feeding of FO led to a significant rise of EPA and DHA in liver TG, PC and PE at the expense of n-6 PUFA (except LA in PC and PE).”

“Addition of cholesterol to linseed oil or fish oil diets decreased the microsomal membrane content of phosphatidylethanolamine species containing six double bonds and increased the membrane content of species containing one double bond.”

“ Feeding fish oil or linseed oil diets resulted in an increased membrane content of phosphatidylethanolamine species containing six double bonds for both microsomal and synaptic plasma membranes, compared with soya-bean oil- or sunflower oil-fed animals.”