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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Fish Oils
drug:
Leukotriene B4
Research Papers that Mention the Interaction
“RESULTS Fi h oil su pplementation resulted in a significant decrease in rectal dialysate levels of leu kotriene B4 fr om 71.0 to 27.7 pg/mL (average change, -43.3 pg/mL; 95% CI, -83 to -3.6).”
Dietary supplementation with fish oil in ulcerative colitis.“ Fish oil decreased neutrophil leukotriene B4 (LTB4) generation following calcium ionophore stimulation by 33%, while leukotriene B5 levels increased significantly.”
“After dietary supplementation with fish oil there was a 50% inhibition of total LTB ( LTB4 + LTB5) generation by ionophore stimulated neutrophils and neutrophil chemotaxis was substantially suppressed.”
“… fish oil produced 78-fold (P = .…-fold (P = .003) more LTB4 compared with predietary levels, and 17.6-fold (P = .01) and 3.3-fold (P = .02), respectively, more than … the ratio of LTB5 to LTB4 concentrations was 4.0-fold (P = .002) higher in horses fed fish oil.”
Dietary (n-3) fatty acids from menhaden fish oil alter plasma fatty acids and leukotriene B synthesis in healthy horses.“Hence, fish oil decreases production of prostaglandins like PGE2 and of leukotrienes like LTB4.”
“…,fish oil consumption led to an increase in leukotriene B5/ leukotriene B4 and significant decreases in IL-6, tumor necrosis factor-α, and nuclear factor-κB. Furthermore, the overall changes in tumor necrosis factor-α and nuclear factor-κB were positively associated (R(2) = 0.295, P < 0.001).”
“ Fish oil supplementation has been shown to reduce neutrophil production of inflammatory LTB4 ( leukotriene B4 ) in adults.”
“Neutrophil LTB4 production was significantly reduced in neonates whose mothers had received fish oil in pregnancy.”
“There was a significant reduction in LTB4 and a significant increase in LTB5 generation from activated PMNLs on the fish oil diet compared to the normal and placebo diets.”
“Since leukotriene B4 is quantitatively the main chemotactic signal in the mucosa in inflammatory bowel disease during relapse, we investigated the therapeutic effect of suppressing leukotriene B4 synthesis by treating patients with fish oil (as Hi-EPA), giving 4.5 g daily of eicosapentaenoic acid.”
“Biologic changes induced by fish oils include decreases in the production of leukotriene B4 , platelet activating factor and interleukin-1.”
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