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Last Updated: 2 months ago

Possible Interaction: Fish Oils and Leukotriene B4

supplement:

Fish Oils

Research Papers that Mention the Interaction

CONCLUSIONS Four months of diet supplementation with fish oil in patients with inflammatory bowel disease resulted in reductions in rectal dialysate leukotriene B4 levels, improvements in histologic findings, and weight gain.
RESULTS Fish oil supplementation resulted in a significant decrease in rectal dialysate levels of leukotriene B4 from 71.0 to 27.7 pg/mL (average change, -43.3 pg/mL; 95% CI, -83 to -3.6).
Annals of internal medicine  •  1992  |  View Paper
Fish oil decreased neutrophil leukotriene B4 (LTB4) generation following calcium ionophore stimulation by 33%, while leukotriene B5 levels increased significantly.
Metabolism: clinical and experimental  •  1992  |  View Paper
After dietary supplementation with fish oil there was a 50% inhibition of total LTB ( LTB4 + LTB5) generation by ionophore stimulated neutrophils and neutrophil chemotaxis was substantially suppressed.
Thorax  •  1988  |  View Paper
…,fish oil consumption led to an increase in leukotriene B5/ leukotriene B4 and significant decreases in IL-6, tumor necrosis factor-α, and nuclear factor-κB. Furthermore, the overall changes in tumor necrosis factor-α and nuclear factor-κB were positively associated (R(2) = 0.295, P < 0.001).
Nutrition  •  2012  |  View Paper
Fish oil supplementation has been shown to reduce neutrophil production of inflammatory LTB4 ( leukotriene B4 ) in adults.
Neutrophil LTB4 production was significantly reduced in neonates whose mothers had received fish oil in pregnancy.
Clinical science  •  2007  |  View Paper
Biologic changes induced by fish oils include decreases in the production of leukotriene B4 , platelet activating factor and interleukin-1.
Rheumatic diseases clinics of North America  •  1991  |  View Paper
Neutrophil leukotriene B4 release was reduced 78 and 42%, respectively, by the low and higher doses of fish oil.
Kidney international  •  1989  |  View Paper
FO attenuated levels of lipoxin and leukotriene B4 while plant oils increased pro-resolving mediator concentrations including D, E and T-series resolvins.
Molecular nutrition & food research  •  2020  |  View Paper
fish oil produced 78-fold (P = .…-fold (P = .003) more LTB4 compared with predietary levels, and 17.6-fold (P = .01) and 3.3-fold (P = .02), respectively, more than … the ratio of LTB5 to LTB4 concentrations was 4.0-fold (P = .002) higher in horses fed fish oil.
Journal of veterinary internal medicine  •  2004  |  View Paper
Hence, fish oil decreases production of prostaglandins like PGE2 and of leukotrienes like LTB4.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2003  |  View Paper
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