Possible Interaction: Fish Oils and Insulin

“Dietary supplementation of fish oils (n-3 PUFA) have been observed to affect insulin action and hence metabolism, affecting the ability to carry out work.”

“BackgroundAn important inter-individual variability in the response of insulin sensitivity following a fish oil supplementation has been observed.”

“Basal insulin concentrations were unaltered by fish oil without or with glyburide; however, postprandial insulin concentrations were decreased by fish oil.”

“Compared with CO (n = 32), FO (n = 36) significantly reduced fasting insulin by -1.62 μIU/L (95%CI: -2.99, -0.26,) (p = 0.021) and HOMA-IR by -0.40 units (95%CI: -0.78, -0.02, p = 0.038).”

“Higher insulin and HOMA-IR at baseline were associated with greater reductions in the FO group (p < 0.001).”

“ Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis.”

“The fish oil supplementation significantly decreased plasma insulin concentration and Homeostatic Model Assesment for Insulin Resistance (HOMA-IR) index and reduced content of adipose tissue biologically active lipids in comparison with HFD-fed subjects.”

“ Fish oil enhances insulin sensitivity by increasing plasma adiponectin; however, the beneficial effect of FF on insulin resistance seems to be independent of the plasma adiponectin level.”

“These results suggest that long-term fish oil supplementation improves insulin sensitivity in association with increased insulin-stimulated p38 activation and decreased n-6:n-3 ratio in skeletal muscle and decreased global DNA methylation in liver.”

“All three fish oil treatments significantly reduced plasma insulin levels.”

“CONCLUSION Chromium and fi h oil po ssible depress the high level of leptin and ins ulin in obese model rats.”