Possible Interaction: Fish Oils and Glutathione

“Collectively, our findings in the ROT model allow us to hypothesize that the prophylactic protection offered by FO may be due to its ability to enhance GSH levels, antioxidant machinery, offset protein oxidation and specific modulatory effects on brain mitochondria.”

“However, FO supplements significantly enhanced the GSH levels in all brain regions examined, while differential effect was discernible in the activity levels of antioxidant enzymes.”

“ Fish oil supplementation significantly reduced atheroma and increased glutathione reductase and glutathione peroxidase activities and blood glutathione levels, but increased plasma lipid peroxide levels.”

“ Fish oil decreased liver total glutathione (TGSH) levels.”

“Further fish oil ingestion increased the glutathione (GSH) content in rat liver; however, this was not effective in protecting liver from APAP-induced toxicity.”

“ Renal glutathione content was significantly (P < 0.05) increased by 23% in normal rats receiving FO diet and by 34% in rats receiving combined DMTU + FO compared with CO alone.”