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Last Updated: 2 months ago

Possible Interaction: Fish Oils and Fluorouracil

supplement:

Fish Oils

Research Papers that Mention the Interaction

A significant increase in mitochondrial membrane depolarisation was observed after the combination of 5-FU or IRI with FOE in HT-29 but not in LS174T cells (P <0.05).
In contrast to SOE, co-treatment with FOE enhanced significantly the pro-apoptotic and cytotoxic effects of 5-FU , OX or IRI in HT-29 but not in LS174T cells (two-way ANOVA, P <0.01).
The British journal of nutrition  •  2013  |  View Paper
CONCLUSIONS A lipid emulsion containing FO has a growth inhibitory effect on a human colon adenocarcinoma cell line, an effect not due to the induction of apoptosis, and potentiated the S phase-halting effect of FU.
CONCLUSIONS A lipid emulsion containing FO has a growth inhibitory effect on a human colon adenocarcinoma cell line, an effect not due to the induction of apoptosis, and potentiated the S phase-halting effect of FU.
Clinical nutrition  •  2010  |  View Paper
The increased pro-apoptotic effect by synergism of 5-fluorouracil and fish oil may be attributed to the incorporation of n-3 polyunsaturated fatty acids in membrane, which alters membrane fluidity in cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine  •  2017  |  View Paper
Additionally, FO ameliorated hematologic depression, gastrointestinal, hepatic and renal toxicity caused by 5-FU as substantiated by a marked improvement in structural and functional alterations of these organs.
ConclusionThe supplementation of FO is potentially a promising option for increasing the therapeutic potential and mitigating the side effects of 5-FU.
ResultsIn the present study, 5-FU in combination with FO increased the survival rate in carcinogen-treated animals.
Synergism of 5-FU and FO was also reflected in significant inhibition in tumor growth and serum sialic acid levels in DMH/DSS model.
Cancer Chemotherapy and Pharmacology  •  2014  |  View Paper