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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Fish Oils and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Multiple regression analyses indicated that suppression of glutathione peroxidase (GPX) activity by FOC prior to DOX therapy was more important than increased LPO as an explanation of tumor growth suppression.
Cancer Cell International  •  2002  |  View Paper
Thus, a small amount of FOC increased the effectiveness of DOX but did not increase the toxicity of DOX to the host mouse.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2001  |  View Paper
However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression.
Cancer letters  •  2000  |  View Paper
Fish oil and vitamin E appeared to enhance the antitumor effect of optimal doses of DOX but to aggravate cardiotoxicity owing to DOX overdose.
On the other hand, DOX at 12.0 mg/kg induced severe heart damage, which was also significantly aggravated by both fish oil and vitamin E, as shown by both decreased LS and increased serum creatine phosphokinase activity.
Lipids  •  2002  |  View Paper