Possible Interaction: Fish Oils and Aldesleukin

“A number of studies showed that …, or chickens diets rich in fish oil results in suppressed … (8-13), interleukin-2 (IL-2) production (14), natural killer (NK) cell activity (12,15-17), cytokine [(IL1, IL-… factor (TNF)] production by inflammatory macrophages (18-20), and macrophage-mediated cytotoxicity (20-22).”

“However, FO supplementation increased lymphocyte proliferation before and after the marathon, and before the race, FO supplementation decreased IL-2 , TNF-α, and IL-10 production in concanavalin-A-stimulated lymphocytes (by 55%, 95%, and 58%, respectively) compared with cells from the C group.”

“Results also indicate that maternal consumption of fish oil increased the expression of genes associated with immune system activation (Ccl20, Cd5, Il2 , Lef1, Lta).”

“The expression of CD25 and CD154, IL-2 level, and NF-kappaB activation were markedly reduced by fish oil.”

“After stimulation, flaxseed oil and fish oil blunted T-lymphocyte interleukin-2 production and subsequent proliferation, which was associated with the lack of incraased acyl-CoA binding protein expression.”

“With respect to PKCθ effector pathway signaling, both AP-1 and NF-κB activation, IL-2 secretion, and lymphoproliferation were inhibited by fish oil feeding.”

“MAIDS infection depressed interleukin-2 (IL-2) and interferon-gamma (IFNgamma), while fish oil partially prevented the depression of IL-2.”

“The results suggest that fish oil may slow down the progression of murine AIDS by modulating levels of cytokines including TNF-alpha, IL-1beta, and IL-2.”