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“ Finasteride increased mean serum androstenedione levels by 17% (P = 0.10) and significantly increased the androstenedione to 17-hydroxyprogesterone ratio (P = 0.02 before ACTH and 0.05 after ACTH).”
The Journal of clinical endocrinology and metabolism • 1994 | View Paper
“Mean perfusate corticotropin-releasing hormone (CRH), plasma adrenocorticotropin (ACTH) and cortisol concentrations were significantly higher in sheep treated with finasteride , stress and finasteride in combination with stress compared to controls.”
“The effects of FIN on FST responses were associated with a dramatic decrease in corticotropin release hormone (CRH) mRNA and adrenocorticotropic hormone (ACTH) levels.”
“Correspondingly, treatment of intact male rats with the 5α-reductase inhibitor, finasteride , for 48 h, enhanced the CORT and ACTH response to restraint stress.”