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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Finasteride
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Finasteride increased mean serum androstenedione levels by 17% (P = 0.10) and significantly increased the androstenedione to 17-hydroxyprogesterone ratio (P = 0.02 before ACTH and 0.05 after ACTH).”
Effect of finasteride on adrenal steroidogenesis in men.“Conversely, finasteride blunted the F response to corticotropin stimulation.”
“Mean perfusate corticotropin-releasing hormone (CRH), plasma adrenocorticotropin (ACTH) and cortisol concentrations were significantly higher in sheep treated with finasteride , stress and finasteride in combination with stress compared to controls.”
Involvement of neurosteroids in the control of hypothalamic-pituitary-adrenal axis activity in pregnant sheep under basal and stressful conditions.“The effects of FIN on FST responses were associated with a dramatic decrease in corticotropin release hormone (CRH) mRNA and adrenocorticotropic hormone (ACTH) levels.”
“Correspondingly, treatment of intact male rats with the 5α-reductase inhibitor, finasteride , for 48 h, enhanced the CORT and ACTH response to restraint stress.”
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